Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Activational effects of testosterone on cognitive function in men.

D B O'Connor1, J Archer, W M Hair

  • 1Department of Endocrinology, Manchester Royal Infirmary, University of Manchester, Manchester M13 9WL, UK. daryloc@psychology.leeds.ac.uk

Neuropsychologia
|October 5, 2001
PubMed
Summary

Higher testosterone levels impaired spatial abilities but improved verbal fluency in eugonadal men. This study explored testosterone

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Complete mitochondrial genomes of four pharyngodonid nematodes reveal extensive gene order rearrangement.

Journal of helminthology·2026
Same author

Evaluating the morality of violence against robots.

Scientific reports·2025
Same author

Considering late effects costs in radiotherapy funding.

The British journal of radiology·2025
Same author

Radiotherapy commissioning and tariff-how can we deliver advanced, innovative, and personalised radiotherapy?

The British journal of radiology·2025
Same author

Sustainable capital funding for modern and innovative radiotherapy services.

The British journal of radiology·2025
Same author

A first report of Pseudosuccinea columella (Say, 1817), an alien intermediate host for liver fluke, in Malawi.

Parasites & vectors·2024

Area of Science:

  • Neuroendocrinology
  • Cognitive Neuroscience

Background:

  • Testosterone's (T) established role in male sexual function contrasts with limited understanding of its cognitive effects.
  • Investigating T's impact on cognitive abilities is crucial for a comprehensive understanding of its physiological roles.
  • Sex-typed cognitive abilities, including spatial and verbal domains, may be differentially influenced by hormone levels.

Purpose of the Study:

  • To examine the relationship between testosterone levels and sex-typed cognitive performance in eugonadal and hypogonadal men.
  • To assess the differential effects of supraphysiological and physiological testosterone levels on cognitive functions.
  • To compare cognitive performance between eugonadal men receiving testosterone or placebo and hypogonadal men receiving testosterone replacement.

Main Methods:

Related Experiment Videos

  • A single-blind, placebo-controlled study design was utilized.
  • Participants included 30 healthy eugonadal men and 7 hypogonadal men.
  • Eugonadal men received weekly intramuscular injections of 200 mg testosterone enanthate (supraphysiological) or placebo for 8 weeks. Hypogonadal men received 200 mg testosterone enanthate bi-weekly (physiological replacement). Neuropsychological tests and testosterone levels were measured at baseline, week 4, and week 8.

Main Results:

  • A significant interaction effect was observed in spatial ability (block design test), with the testosterone group showing performance decline compared to placebo.
  • The testosterone group demonstrated significantly improved verbal fluency (Controlled Oral Word Association Test) at week 4 compared to the placebo group.
  • Hypogonadal men generally performed less well on all cognitive tests compared to eugonadal groups.

Conclusions:

  • Increased testosterone levels appear to have a differential impact on cognitive function in eugonadal men.
  • Evidence suggests testosterone may inhibit spatial abilities while enhancing verbal fluency.
  • Further research is warranted to elucidate the mechanisms underlying testosterone's complex effects on cognition.