Protective role of Delphinium denudatum (Jadwar) against morphine induced tolerance and dependence in mice
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Updated: Oct 4, 2026

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
S Zafar1, M A Ahmad, T A Siddiqui
1Department of Ilmul Advia (Pharmacology), Faculty of Medicine (Unani), Hamdard University, Hamdard Nagar, 110062, New Delhi, India. shadabzafar@rediffmail.com
Abstract:
Chronic treatment with Delphinium denudatum (Dd) (Jadwar) (family: Ranunculaceae, 200-1600 mg/kg) suppressed morphine withdrawal jumps in a dose-dependent manner, a sign of the development of dependence to opiate as assessed by naloxone (2 mg/kg) precipitation withdrawal on day 10 of testing in mice. Repeated administration of Dd (200-1600 mg/kg) for 9 days attenuated the development of tolerance to the analgesic effect of morphine (10 mg/kg), also produces significant change in tail-flick latency from the saline pretreated group in a dose-dependent manner.
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