Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Improving chemoradiotherapy in rectal cancer.

R Glynne-Jones1, J Debus

  • 1Mount Vernon Hospital, London, UK. rgjones@mtvern.co.uk

The Oncologist
|October 5, 2001
PubMed
Summary

Optimal rectal cancer management differs globally. Preoperative chemoradiation with oral capecitabine shows promise, potentially replacing 5-FU for improved outcomes and patient experience.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neoadjuvant irradiation of extremity soft tissue sarcoma with ions (Extrem‑ion): Interim report of a randomized phase II pilot trial.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

A model-based risk-minimizing proton treatment planning concept for brain injury prevention in low-grade glioma patients.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2024
Same author

Spectroscopic Study of Strain, Oxidation, and Formation of Few-Layer Graphene at Steel Surfaces Tribologically Tested against MoS<sub>2</sub> Films.

ACS applied materials & interfaces·2024
Same author

Online MR-guided proton and ion beam radiotherapy: investigation of image quality.

Physics in medicine and biology·2024
Same author

Fractionated stereotactic radiotherapy of intracranial postoperative cavities after resection of brain metastases - Clinical outcome and prognostic factors.

Clinical and translational radiation oncology·2024
Same author

Stereotactic ultrahypofractionated MR-guided radiotherapy for localized prostate cancer - Acute toxicity and patient-reported outcomes in the prospective, multicenter <i>SMILE</i> phase II trial.

Clinical and translational radiation oncology·2024

Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiotherapy

Background:

  • Rectal cancer management, particularly for stage II/III, faces challenges with local recurrence and survival.
  • Divergent global standards exist: U.S. favors postoperative chemoradiation, while Europe emphasizes preoperative treatment based on imaging and surgical margins.

Purpose of the Study:

  • To review clinical trials influencing differing rectal cancer treatment standards.
  • To explore the novel use of capecitabine combined with radiotherapy for rectal cancer.

Main Methods:

  • Review of clinical trials comparing preoperative and postoperative adjuvant therapies for rectal cancer.
  • Evaluation of preclinical data and Phase I study on capecitabine and radiotherapy combination.

Main Results:

  • Preoperative radiotherapy and chemoradiation aim for curative resection and sphincter preservation.
  • Capecitabine plus radiotherapy demonstrates enhanced antitumor activity, potentially due to upregulated thymidine phosphorylase.
  • A Phase I study established a feasible chemoradiotherapy combination using capecitabine.

Conclusions:

  • Capecitabine shows potential to replace 5-fluorouracil (5-FU) in rectal cancer treatment, offering an improved therapeutic ratio.
  • Oral capecitabine simplifies chemoradiation and enhances patient compliance and quality of life.

Related Experiment Videos