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Large B-cell lymphoma of the leg--complete remission with perilesional interferon alpha
U Wollina1, T Mentzel, T Graefe
1Department of Dermatology and Allergology, Friedrich Schiller University of Jena, Germany. uwol@derma.uni-jena.de
Dermatology (Basel, Switzerland)
|October 5, 2001
Abstract:
We present the case of an 85-year-old woman with cutaneous and subcutaneous nodules on the lower and upper leg showing the characteristic histological features of a large B-cell lymphoma of the leg. Investigations for non-Hodgkin's lymphoma with the prognostic markers matrix metalloproteinase 2 and soluble intercellular adhesion molecule 1 revealed an increased serum level of the latter. Monotherapy with perilesional interferon alpha(2a) 3 x 9 million units/week was well tolerated. The final outcome was a complete remission after 14 months with an overall survival of more than 17 months.