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Related Experiment Videos

Schedule-dependent pulsed paclitaxel radiosensitization for thoracic malignancy.

Y Chen1, K Pandya, P P Keng

  • 1Department of Radiation Oncology, James P. Wilmot Cancer Center, University of Rochester, Rochester, New York, USA.

American Journal of Clinical Oncology
|October 5, 2001
PubMed
Summary

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Pulsed low-dose paclitaxel combined with radiation therapy shows significant tumor shrinkage and high response rates in thoracic malignancy patients. This effective and well-tolerated regimen offers a promising treatment option.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Oncology

Background:

  • Preclinical research investigated paclitaxel's radiosensitizing effects on thoracic malignancy.
  • Human lung cancer (NCI520) and epidermoid (A431) cell lines were used for in vitro studies.
  • Optimal paclitaxel treatment schedules were explored for clinical application.

Purpose of the Study:

  • To evaluate the efficacy and safety of pulsed low-dose paclitaxel with concurrent radiation for thoracic malignancy.
  • To determine the optimal dose escalation of paclitaxel in combination with radiation.
  • To assess tumor response and toxicity in a Phase I clinical trial.

Main Methods:

  • A Phase I clinical trial involving dose escalation of pulsed paclitaxel (15, 20, 25 mg/m2) with concurrent daily radiation.

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  • Paclitaxel was administered every 48 hours.
  • Tumor shrinkage and response rates were assessed 4-6 weeks post-therapy.

    • Main Results:

    • Seventeen patients completed treatment across three dose levels.
    • Mean tumor shrinkage averaged 83% +/- 8%.
    • A 100% locoregional tumor response rate was observed (12% complete, 88% partial response) with low toxicity.

    Conclusions:

    • Pulsed low-dose paclitaxel combined with radiation is a highly effective and well-tolerated treatment for thoracic malignancy.
    • Preclinical findings support the efficacy of low-dose paclitaxel for radiosensitization.
    • The study supports delaying radiation after drug administration for better outcomes.