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Related Experiment Videos

Acute mania and hemichorea.

R Inzelberg1, P Nisipeanu, D Joel

  • 1Department of Neurology, Hillel Yaffe Medical Center, Hadera, Israel.

Clinical Neuropharmacology
|October 5, 2001
PubMed
Summary

A rare case of hemichorea and mania occurred after a right thalamic infarction. This suggests thalamic lesions can disrupt basal ganglia thalamocortical circuits, causing these neurological and psychiatric symptoms.

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Area of Science:

  • Neuroscience
  • Neurology
  • Psychiatry

Background:

  • Thalamic lesions are known to cause various neurological deficits.
  • Manic episodes are typically associated with mood disorders, not focal brain lesions.

Observation:

  • A 61-year-old male presented with sudden euphoria, talkativeness, and left-sided hemichoreic movements.
  • The patient met DSM-IV criteria for a manic episode, including elevated mood, decreased sleep, distractibility, pressured speech, increased activity, and hypersexuality.

Findings:

  • Magnetic resonance imaging revealed a right thalamic infarction.
  • The co-occurrence of hemichorea and mania was attributed to this focal thalamic lesion.

Implications:

  • This case highlights the potential for thalamic lesions to induce complex neuropsychiatric symptoms.

Related Experiment Videos

  • The findings suggest a possible disruption of basal ganglia thalamocortical circuitry in the pathogenesis of these symptoms.
  • This rare presentation expands our understanding of the relationship between focal brain lesions and mood disturbances.