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The penetration of cefoperazone and sulbactam into the lumbar intervertebral discs
1Department of Neurosurgery, Faculty of Medicine, Selçuk University, Konya, Turkey.
Journal of Spinal Disorders
|October 5, 2001
Abstract:
Six patients received 1 g and six other patients received 2 g of cefoperazone and sulbactam 15 minutes before lumbar disc surgery. Liquid chromatographic analysis of disc tissue revealed that only patients receiving the 2-g dose had mean tissue levels above the minimum inhibitory concentration for Staphylococcus aureus and epidermidis.