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Related Concept Videos

Humoral Immune Responses01:36

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
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Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
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Related Experiment Video

Updated: Jul 2, 2026

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting
11:58

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

Antibody-directed therapy: past, present, and future.

E W Gelfand1

  • 1Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA.

The Journal of Allergy and Clinical Immunology
|October 5, 2001
PubMed
Summary
This summary is machine-generated.

Antibody-based therapies, including intravenous immunoglobulin, offer potent immunomodulatory effects for various diseases. This review explores current and future applications of antibody therapies.

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Last Updated: Jul 2, 2026

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Targeted Antibody Blocking by a Dual-Functional Conjugate of Antigenic Peptide and Fc-III Mimetics (DCAF)
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Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
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Area of Science:

  • Immunology
  • Therapeutics

Background:

  • Antibody-based therapy is a key treatment for numerous diseases.
  • Intravenous immunoglobulin (IVIg) is widely used for antibody-deficiency diseases and exhibits immunomodulatory effects.

Purpose of the Study:

  • To review current and future prospects of antibody-based therapies.
  • To discuss the mechanisms behind IVIg's immunomodulatory and anti-inflammatory effects.

Main Methods:

  • Literature review of antibody-based therapies.
  • Analysis of immunomodulatory and anti-inflammatory mechanisms of immunoglobulins.

Main Results:

  • Antibody therapies, including IVIg, are established treatments.
  • The precise mechanisms of IVIg's broad therapeutic effects are still under investigation.

Conclusions:

  • Antibody-based therapies hold significant promise for treating diverse diseases.
  • Further research is needed to elucidate the mechanisms of action for optimal therapeutic strategies.