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Karyotyping

Describing the number and physical features of chromosomes can reveal abnormalities that underlie genetic diseases. This description is facilitated by special staining techniques that produce a particular banding pattern on each chromosome. State-of-the-art techniques make this approach even more powerful, enabling the detection of individual genes that cause disease.A Simple Chromosome Staining Technique Provides Valuable Scientific InsightSome genetic diseases can be detected by looking at...

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Related Experiment Video

Updated: Jul 14, 2026

High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization

High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization

Published on: June 28, 2012

Regional mapping panels for human chromosomes 1, 2, and 7.

J C Leonard¹, L H Toji, P K Bender

¹NIGMS Human Genetic Cell Repository, Coriell Cell Repositories, Coriell Institute for Medical Research, Camden, New Jersey 08103, USA.

Somatic Cell and Molecular Genetics

|October 6, 2001

Summary

The NIGMS Human Genetic Cell Repository created new regional mapping panels for human chromosomes 1, 2, and 7 using somatic cell hybrids. These panels provide valuable resources for genetic mapping and research.

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Last Updated: Jul 14, 2026

High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization

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Published on: June 28, 2012

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Published on: February 21, 2015

Area of Science:

Genetics
Genomics
Cell Biology

Background:

The National Institute of General Medical Sciences (NIGMS) Human Genetic Cell Repository collects and distributes human genetic materials.
Regional mapping panels are essential tools for localizing genes on chromosomes.

Purpose of the Study:

To assemble and validate regional mapping panels for human chromosomes 1, 2, and 7.
To provide researchers with new resources for human genetic mapping.

Main Methods:

Human rodent somatic cell hybrids from 14 laboratories were collected and characterized.
Each hybrid was verified to contain a stable, defined human chromosomal segment.
Panels were designed to define 8-10 intervals per chromosome.

Main Results:

Regional mapping panels for human chromosomes 1, 2, and 7 have been established.
The chromosome 2 panel is a novel resource, while panels for chromosomes 1 and 7 complement existing ones.
These panels consist of cell cultures or DNA derived from verified somatic cell hybrids.

Conclusions:

The NIGMS Repository has successfully created and validated new regional mapping panels for human chromosomes.
These panels serve as critical resources for precise genetic mapping and research.
The Repository offers these panels, along with information on numerous other chromosome panels, via its electronic catalog.