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Cyclic red blood cell destruction in thalassemia
1Department of Preventive Medical Sciences, Faculty of Medicine, University of Naples, Italy. ugiani@cds.unina.it
Chronobiology International
|October 6, 2001
Abstract:
A retrospective analysis of time series of hemoglobin (Hb) destruction of 24 children (11 males and 13 females) with thalassemia from the age of 6 to 12 years showed that the Hb destruction rate typically oscillated with an average period of 50 days. A possible relation between the periodism and the severity of the disease is also suggested.