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Vascular cell adhesion molecule-1 as a biochemical marker of left ventricular mass in the patients with hypertension

Y T Kuroda1, K Komamura, R Tatsumi

  • 1Osaka Second Police Hospital, Ibaraki, Japan.

American Journal of Hypertension
|October 6, 2001
PubMed

Insights

In essential hypertension patients, elevated soluble vascular adhesion molecule-1 (sVCAM-1) levels correlate with left ventricular hypertrophy. This finding suggests sVCAM-1 may indicate cardiac changes in hypertension.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Biomarker Discovery

Background:

  • Essential hypertension is a common cardiovascular risk factor.
  • Left ventricular (LV) hypertrophy is a significant complication of hypertension.
  • Adhesion molecules play roles in vascular inflammation and remodeling.

Purpose of the Study:

  • To investigate the association between plasma levels of soluble adhesion molecules and left ventricular hypertrophy in patients with uncomplicated essential hypertension.
  • To determine if specific adhesion molecules like sVCAM-1, sICAM-1, and E-selectin are elevated in hypertensive patients with LV hypertrophy.

Main Methods:

  • Measured plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular adhesion molecule-1 (sVCAM-1), and E-selectin in 80 outpatients with essential hypertension.
  • Assessed for the presence of left ventricular (LV) hypertrophy.
  • Correlated adhesion molecule levels with LV mass indexed to body surface area and height.

Main Results:

  • Plasma sVCAM-1 levels were significantly elevated in hypertensive patients with LV hypertrophy compared to those without (984.4+/-240.6 ng/mL vs. 759.7+/-154.6 ng/mL, P < .0001).
  • No significant differences in E-selectin and sICAM-1 levels were observed between groups.
  • LV mass was significantly correlated with sVCAM-1 levels (r=0.615 and r=0.571, P < .0001).

Conclusions:

  • Elevated sVCAM-1 levels are associated with left ventricular hypertrophy in patients with uncomplicated essential hypertension.
  • sVCAM-1 may serve as a potential biomarker for cardiac structural changes in hypertensive individuals.
  • Further research is warranted to explore the pathogenetic role of sVCAM-1 in hypertensive cardiac remodeling.

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