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Related Experiment Videos

Non-Hodgkin's orbital lymphoma.

S C Lutz1, S F Anderson, C Y Wu

  • 1Primary Eye Care, Department of Veterans Affairs, VA Greater Los Angeles Healthcare System, Sepulveda Ambulatory Care Center and Nursing Home, Sepulveda, California, USA. msltz@msn.com

Optometry and Vision Science : Official Publication of the American Academy of Optometry
|October 6, 2001
PubMed
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Orbital lymphoma, a manifestation of non-Hodgkin's lymphoma (NHL), can affect vision. External beam irradiation therapy is a standard treatment, but careful dosage is needed to avoid complications like radiation retinopathy.

Area of Science:

  • Ophthalmology
  • Oncology
  • Hematology

Background:

  • Non-Hodgkin's lymphoma (NHL) comprises malignant lymphocyte proliferation, with varied presentations based on disease site and aggressiveness.
  • Ocular and orbital involvement can occur in patients with NHL, presenting diverse signs and symptoms.

Observation:

  • A 47-year-old male with stage IV NHL experienced blurred vision and diplopia.
  • Ocular examination revealed ptosis, proptosis, elevated intraocular pressure, and choroidal folds in the left eye.
  • MRI confirmed orbital lymphoma, which resolved after 2400 rads of external beam irradiation therapy.

Findings:

  • Orbital lymphoma is a potential complication of NHL, requiring prompt diagnosis and management.
  • External beam irradiation therapy effectively treated the orbital lymphoma in this case.

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  • The patient later developed secondary radiation retinopathy, highlighting a potential treatment complication.

    • Implications:

    • Orbital lymphoma requires consideration in NHL patients presenting with ocular symptoms.
    • External beam irradiation is a primary treatment modality, but optimal dosing requires further investigation to balance efficacy and toxicity.
    • Understanding treatment-related complications like radiation retinopathy is crucial for long-term patient care.