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Anticancer Metal Complexes: Synthesis and Cytotoxicity Evaluation by the MTT Assay
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Published on: November 11, 2013

Arsenic compounds as anticancer agents.

Z Y Wang1

  • 1Shanghai Institute of Hematology, Rui-jin Hospital, Shanghai Second Medical University, People's Republic of China.

Cancer Chemotherapy and Pharmacology
|October 6, 2001
PubMed
Summary
This summary is machine-generated.

Arsenic compounds, including arsenic trioxide, show high remission rates for acute promyelocytic leukemia (APL). Further research is needed to explore their effectiveness against other cancer types.

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Area of Science:

  • Oncology
  • Pharmacology
  • Toxicology

Background:

  • Arsenic compounds have a historical and emerging role in cancer treatment.
  • Acute promyelocytic leukemia (APL) is a specific type of cancer where arsenic has shown promise.

Purpose of the Study:

  • To review the use of arsenic compounds in clinical trials and in vitro for cancer treatment.
  • To summarize the efficacy of arsenic trioxide (As2O3) and other arsenic compounds in treating APL and other cancers.

Main Methods:

  • Review of clinical trial data and in vitro investigations on arsenic compounds.
  • Analysis of treatment outcomes, including complete remission (CR) rates and response times.
  • Examination of arsenic's in vitro effects on cancer cell lines at varying concentrations.

Main Results:

  • Arsenic trioxide (As2O3) achieved 85-93% CR rates in APL patients within 28-42 days.
  • Composite Indigo Naturalis and tetraarsenic tetrasulfide demonstrated high CR rates (98% and 84.9%) in APL.
  • In vitro studies showed As2O3 induced apoptosis at higher concentrations and cell differentiation at lower concentrations in various cancer cell lines.

Conclusions:

  • Arsenic compounds, particularly As2O3, are effective in treating APL.
  • As2O3 demonstrates efficacy in treating multiple myeloma.
  • The potential of arsenic compounds against other cancers warrants further investigation.