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Updated: Jul 15, 2026

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function
Published on: October 15, 2013
Mental stimulation increases circulating CD4-positive T lymphocytes: a preliminary study
M C Diamond1, J Weidner, P Schow
1Department of Integrative Biology, 3060 Valley Life Sciences Building, University of California, Berkeley, CA 94720-3140, USA. diamond@socrates.berkeley.edu
Abstract:
To stimulate the dorsolateral frontal cortex, 12 healthy, adult, human females played contract bridge for 1.5 h between initial and final blood sample collections. Flow cytometric analyses of samples, performed in triplicate, showed a significant increase in CD4-positive T lymphocytes. The dorsolateral frontal cortical thickness is significantly and bilaterally reduced in immune-incompetent female, nude mice. Thymic transplants reverse the deficient cortical thickness and CD4-positive cell numbers.

