Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integrons: natural tools for bacterial genome evolution.

D A Rowe-Magnus1, D Mazel

  • 1Unité de Programmation Moléculaire et Toxicologie Génétique, Centre National de la Recherche Scientifique URA 1444, Département des Biotechnologies, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France.

Current Opinion in Microbiology
|October 6, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Photoregulation of gene expression in the filamentous cyanobacterium Calothrix sp. PCC 7601: light-harvesting complexes and cell differentiation.

Photosynthesis research·2014
Same author

β-Lactam antibiotics promote bacterial mutagenesis via an RpoS-mediated reduction in replication fidelity.

Nature communications·2013
Same author

Healthcare-associated infections: think globally, act locally.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2008
Same author

Impact of integrons and transposons on the evolution of resistance and virulence.

Current topics in microbiology and immunology·2002
Same author

Molecular analysis of antibiotic resistance gene clusters in vibrio cholerae O139 and O1 SXT constins.

Antimicrobial agents and chemotherapy·2001
Same author

The evolutionary history of chromosomal super-integrons provides an ancestry for multiresistant integrons.

Proceedings of the National Academy of Sciences of the United States of America·2001

Integrons capture and spread antibiotic resistance genes in bacteria. Larger super-integrons are key components of bacterial genomes, driving genome evolution and the emergence of new species.

Area of Science:

  • Microbiology
  • Genomics
  • Evolutionary Biology

Background:

  • Integrons are mobile genetic elements crucial for antibiotic resistance gene acquisition in Gram-negative bacteria.
  • Super-integrons, large integron structures, are integral components of many gamma-proteobacterial genomes.
  • Integron gene cassettes confer adaptive advantages, enhancing bacterial survival and evolution.

Purpose of the Study:

  • To discuss the widespread occurrence and significance of integron systems, particularly super-integrons, in Gram-negative bacteria.
  • To review adaptive functions encoded by integron-associated genes.
  • To highlight the role of integron-mediated evolution in bacterial speciation.

Main Methods:

  • Literature review and synthesis of existing research on integrons and super-integrons.

Related Experiment Videos

  • Analysis of functional data for genes within integron cassettes.
  • Discussion of evolutionary implications based on genomic data.

    • Main Results:

    • Integrons are fundamental for antibiotic resistance dissemination.
    • Super-integrons are widespread genomic features in gamma-proteobacteria with variable gene cassette content.
    • Recruited gene cassettes provide selective advantages, contributing to bacterial adaptation.

    Conclusions:

    • Integron systems, especially super-integrons, play a significant role in bacterial genome evolution.
    • The adaptive functions encoded by integron cassettes contribute to bacterial fitness.
    • Integron-mediated genome evolution is implicated in the emergence of novel bacterial species.