Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Submicrometer metallic barcodes.

S R Nicewarner-Pena1, R G Freeman, B D Reiss

  • 1Department of Chemistry, Pennsylvania State University, 152 Davey Laboratory, University Park, PA 16802, USA., SurroMed Inc., 2375 Garcia Avenue, Mountain View, CA 94043, USA.

Science (New York, N.Y.)
|October 6, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of macromolecular crowding on RNA/spermine complex coacervation and oligonucleotide compartmentalization.

Soft matter·2017
Same author

Controlling and measuring local composition and properties in lipid bilayer membranes.

Journal of biological physics·2013
Same author

Nanoscale characterization of gold colloid monolayers:  a comparison of four techniques.

Analytical chemistry·2011
Same author

Free-standing graphene by scanning transmission electron microscopy.

Ultramicroscopy·2010
Same author

Exogenous cell-permeable C6 ceramide sensitizes multiple cancer cell lines to Doxorubicin-induced apoptosis by promoting AMPK activation and mTORC1 inhibition.

Oncogene·2010
Same author

A positive role for c-Abl in Atm and Atr activation in DNA damage response.

Cell death and differentiation·2010
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
See all related articles

Researchers created unique multimetal microrods with distinct stripe patterns for advanced bioassays. These particles offer a novel method for multiplexed detection using simple light microscopy and fluorescence.

Area of Science:

  • Materials Science
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Multiplexed detection is crucial for high-throughput biological assays.
  • Existing methods for encoding particles often require complex instrumentation.
  • There is a need for simple, yet effective, particle encoding strategies.

Purpose of the Study:

  • To develop novel multimetal microrods with intrinsic, complex striping patterns.
  • To demonstrate a readout mechanism using conventional light microscopy.
  • To show compatibility with fluorescence-based detection for bioassays.

Main Methods:

  • Sequential electrochemical deposition of metal ions into nanoporous templates.
  • Fabrication of multimetal microrods with submicrometer stripes.

Related Experiment Videos

  • Characterization of striping patterns using light microscopy.
  • Demonstration of multiplexed bioassays using DNA and protein targets.

    • Main Results:

    • Successfully synthesized multimetal microrods with precisely controlled submicrometer stripe patterns.
    • Differential reflectivity of adjacent metal stripes allowed for pattern identification via light microscopy.
    • The microscopy-based readout did not impede simultaneous fluorescence detection.
    • Validated the system in DNA and protein binding assays, demonstrating multiplexing capability.

    Conclusions:

    • Multimetal microrods with intrinsic striping patterns offer a versatile platform for multiplexed sensing.
    • The combination of light microscopy readout and fluorescence detection simplifies complex bioassays.
    • This technology has potential applications in diagnostics, drug discovery, and fundamental biological research.