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Updated: Aug 12, 2026

Flow-pattern Guided Fabrication of High-density Barcode Antibody Microarray
Published on: January 6, 2016
Submicrometer metallic barcodes
S R Nicewarner-Pena1, R G Freeman, B D Reiss
1Department of Chemistry, Pennsylvania State University, 152 Davey Laboratory, University Park, PA 16802, USA., SurroMed Inc., 2375 Garcia Avenue, Mountain View, CA 94043, USA.
Abstract:
We synthesized multimetal microrods intrinsically encoded with submicrometer stripes. Complex striping patterns are readily prepared by sequential electrochemical deposition of metal ions into templates with uniformly sized pores. The differential reflectivity of adjacent stripes enables identification of the striping patterns by conventional light microscopy. This readout mechanism does not interfere with the use of fluorescence for detection of analytes bound to particles by affinity capture, as demonstrated by DNA and protein bioassays.

