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Published on: September 12, 2014
Amniotic membrane transplantation in infectious corneal ulcer
1Department of Ophthalmology, Chung-Ang University Hospital, Hangang-Ro 3ka 65-207, Yongsan-ku 140-757, Seoul, Korea.
Purpose:
To evaluate the efficacy of amniotic membrane transplantation in the management of treated infectious corneal ulcer in which inflammatory reactions were responsible for corneal damage.
Method:
A prospective study of 21 consecutive eyes (21 patients) was performed. Sufficient antibacterial, antifungal, or antiviral agents were applied to eradicate causative organisms before permanent or temporary amniotic membrane transplantation, or a combination of the two in few patients. The amniotic membrane was soaked in antiinfective agents before transplantation in all cases.
Results:
After amniotic membrane transplantation, follow-up times ranged from 4 to 28 months (mean, 18 months). Clinical indications included Staphylococcus species (four cases), Pseudomonas species (five cases), Acanthamoeba species (three cases), fungus (two cases), and herpesvirus (seven cases). The corneal surface was healed successfully and recurrences of microbial infection were not noted in any case. Visual acuity was improved in cases that were nonscarring or after additional penetrating keratoplasty.
Conclusion:
Amniotic membrane transplantation seems to be a useful adjunctive surgical procedure for the management of infectious corneal ulcer by promoting wound healing and reducing inflammation.
Insights
Amniotic membrane transplantation effectively managed infectious corneal ulcers by promoting healing and reducing inflammation. This treatment aided corneal surface recovery and improved visual acuity in patients.
Area of Science:
- Ophthalmology
- Regenerative Medicine
Background:
- Infectious corneal ulcers can cause significant corneal damage due to inflammatory responses.
- Effective management strategies are crucial to prevent vision loss.
Purpose of the Study:
- To assess the efficacy of amniotic membrane transplantation (AMT) for treated infectious corneal ulcers.
- To evaluate AMT's role in managing inflammation-induced corneal damage.
Main Methods:
- A prospective study involved 21 patients with infectious corneal ulcers.
- Causative organisms were eradicated with antimicrobial agents prior to AMT.
- Amniotic membranes were soaked in anti-infective agents before transplantation.
Main Results:
- Successful corneal healing was observed in all cases post-AMT.
- No recurrence of microbial infection was noted during the follow-up period (mean 18 months).
- Visual acuity improved in non-scarring cases or after subsequent penetrating keratoplasty.
Conclusions:
- Amniotic membrane transplantation serves as a valuable adjunctive therapy for infectious corneal ulcers.
- AMT promotes wound healing and mitigates inflammation, aiding corneal recovery.
