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Receptor Autoradiography Protocol for the Localized Visualization of Angiotensin II Receptors
Published on: June 7, 2016
Effects of adenosine receptor subtype A1 on ventricular and renal function
D G Lucas1, T Patterson, J W Hendrick
1Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Journal of Cardiovascular Pharmacology
|October 6, 2001
Summary
Selective A1 receptor blockade improved renal function in pigs with congestive heart failure (CHF). This suggests that blocking renal A1 receptor activation may help treat reduced kidney function in CHF patients.
Area of Science:
- Cardiology
- Nephrology
- Pharmacology
Background:
- Adenosine A1 receptors influence cardiac and renal function.
- Their role in congestive heart failure (CHF) is not well understood.
- Reduced renal function is common in CHF.
Purpose of the Study:
- To investigate the effects of A1 receptor inhibition on renal function in a porcine model of CHF.
- To determine if A1 receptor blockade impacts cardiac function in CHF.
Main Methods:
- Pigs with pacing-induced CHF were treated with A1 receptor antagonist BG9719 or vehicle.
- Systemic hemodynamics and renal function indices were measured.
- Measurements were taken before and after drug administration.
Main Results:
- A1 receptor blockade increased heart rate, mean aortic pressure, and left ventricular peak pressure.
- Cardiac output and vascular resistance remained unchanged.
- Urine output, sodium clearance, and creatinine clearance significantly increased.
Conclusions:
- Selective A1 receptor blockade improved glomerular filtration rate and induced diuresis and natriuresis in CHF pigs.
- No adverse effects on cardiac function were observed.
- Renal A1 receptor activation may contribute to impaired renal function in CHF.
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