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Related Experiment Videos

Coccidioidomycosis in solid organ transplantation.

J E Blair1, J L Logan

  • 1Division of Infectious Diseases, Mayo Clinic, Scottsdale, AZ 85259, USA. blair.janis@mayo.edu

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|October 6, 2001
PubMed
Summary

Coccidioidomycosis, a fungal infection in the southwestern US, poses serious risks for solid organ transplant recipients. Early identification and antifungal prophylaxis are crucial to manage this potentially disseminated disease and prevent frequent relapses.

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Transplantation Immunology

Background:

  • Coccidioidomycosis is endemic to the southwestern United States.
  • It is typically self-limited in healthy individuals.
  • However, it presents a significant threat to solid organ transplant (SOT) recipients.

Purpose of the Study:

  • To highlight the clinical presentations of coccidioidomycosis in SOT patients.
  • To emphasize the importance of identifying at-risk patients for early intervention.
  • To discuss management and prophylaxis strategies.

Main Methods:

  • Review of clinical cases and literature concerning coccidioidomycosis in SOT recipients.
  • Analysis of disease presentation, risk factors, and treatment outcomes.

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  • Evaluation of current prophylactic and therapeutic guidelines.

    • Main Results:

    • Coccidioidomycosis in SOT patients frequently presents as disseminated disease.
    • Disseminated coccidioidomycosis leads to substantial morbidity in this population.
    • Variable clinical manifestations are observed.

    Conclusions:

    • Prophylactic antifungal therapy should be initiated for at-risk SOT patients.
    • Treatment options include amphotericin B and azoles.
    • Secondary prophylaxis is essential due to high relapse rates.