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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...

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Related Experiment Video

Updated: Jun 28, 2026

Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model
08:53

Assessing Neuroprotective Effects of Glycyrrhizae Radix et Rhizoma Extract Using a Transient Middle Cerebral Artery Occlusion Mouse Model

Published on: December 9, 2018

Licorice and cancer.

Z Y Wang1, D W Nixon

  • 1American Health Foundation, New York, NY 10017, USA. wangzhiyuan@hotmail.com

Nutrition and Cancer
|October 9, 2001
PubMed
Summary

Licorice root, a traditional Chinese medicine, contains compounds like glycyrrhizic acid and polyphenols that show potential in preventing DNA damage and fighting cancer. Further research is exploring its use in clinical trials.

Area of Science:

  • Pharmacology
  • Ethnobotany
  • Cancer Research

Background:

  • Licorice root (Glycyrrhiza glabra) is a long-established botanical in traditional Chinese medicine.
  • In the US, it's commonly used as a food flavoring and sweetener.
  • Its known constituents include triterpenoids (glycyrrhizin, glycyrrhizic acid), polyphenols, and polysaccharides.

Purpose of the Study:

  • To review the known and suspected pharmaceutical effects of licorice.
  • To explore its potential in cancer prevention and treatment.
  • To suggest a rationale for combining licorice derivatives in clinical trials.

Main Methods:

  • Literature review of pharmacological activities of licorice and its constituents.
  • Analysis of mechanisms of action, including enzyme inhibition and cellular effects.

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  • Evaluation of potential in preventing carcinogen-induced DNA damage.

    • Main Results:

    • Licorice derivatives may protect against DNA damage induced by carcinogens.
    • Glycyrrhizic acid inhibits lipoxygenase, cyclooxygenase, and protein kinase C, and downregulates the epidermal growth factor receptor.
    • Licorice polyphenols have been shown to induce apoptosis in cancer cells.

    Conclusions:

    • Licorice exhibits multiple pharmaceutical properties, including anti-inflammatory, antiviral, antiulcer, and anticarcinogenic effects.
    • Its compounds demonstrate mechanisms relevant to cancer prevention and therapy.
    • Combinations of licorice-derived agents warrant investigation in preventive clinical trials.