[The combined effect of retabolile and support loads on the post-traumatic reparation process in suspended rat...

Histological and histomorphometric technical were used to determine effects of limited support loads and anabolic steroid retabolite on the time course of the post-traumatic reparation of m. soleus and m. gastrocnemius in tail-suspended rats in the 14-d experiment. One day prior to suspension, the muscles were partly crushed after the rats had been anesthetized with the help of artery clamp. Deprivation of the support loading was shown to cause atrophy of m. soleus and, to a less degree, m. gastrocnemius and inhibit the post-traumatic reparation of m. soleus. Neither retabolite injection (at the total dose of 5 mg per 100 g of the body mass) nor daily limited support loading (the rats were free from suspension and could stand on all four limbs 2 hrs a day) could essentially prevent muscle atrophy and enhance reparation. Nonetheless, combination of the support loads with retabolite injection implicitly slowed atrophy and stimulated healing of m. soleus trauma.