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Inclusion body myositis associated with hepatitis C virus infection
1Second Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan. kaseron@grape.med.tottori-u.ac.jp
Liver
|October 9, 2001
Abstract:
The case of a 77-year-old woman with hepatitis C virus infection with a 5-year history of muscle weakness and mild disturbance of gait is reported. Steroid therapy did not improve her symptoms. She developed HCV-related liver cirrhosis and hepatocellular carcinoma, and muscle biopsy revealed inclusion body myositis. Immunohistochemistry showed that the nonstructural region of HCV and 8-hydroxy-2'-deoxyguanosine, a marker of DNA damage by reactive oxygen species, were present in striated muscle cells of this patient.