Related Experiment Videos
Cerebrospinal fluid tau and beta-amyloid(1-42) in dementia disorders
E Vanmechelen1, H Vanderstichele, F Hulstaert
1Innogenetics NV, Industriepark Zwijnaarde 7, Box 4, B-9052, Ghent, Belgium. eugeevme@innogenetics.com
Mechanisms of Ageing and Development
|October 9, 2001
Abstract:
The reliability of cerebrospinal fluid (CSF)-tau and CSF-beta-amyloid assays for diagnosis of Alzheimer's disease and other dementing disorders such as frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and Creutzfeldt-Jakob disease (CJD) is reviewed. CSF assessment of the two proteins is useful in early diagnosis of AD and to differentiate it from FTD and DLB. Extremely high CSF-tau levels can discriminate CJD from AD.