Gas chromatographic determination of micro-amounts of cyclamates

It was found that triethylammonium cyclamate is converted into N-hepta-fluorobutyrylcyclohexylamine in a high and constant yield by reaction with hepta-fluorobutyric anhydride at 90 degrees for 1 h, and gas chromatography of the product gives a sharp peak that is highly sensitive to an electron capture detector. A useful method for the micro-determination of cyclamates was established by combining this reaction with gas chromatography.