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Response of preschool children with asthma symptoms to fluticasone propionate

R J Roorda1, G Mezei, H Bisgaard

  • 1Department of Pediatrics, Isala Klinieken, De Weezenlanden Hospital, Zwolle, The Netherlands.

The Journal of Allergy and Clinical Immunology
|October 9, 2001
PubMed

Insights

Preschool children with frequent asthma symptoms or a family history of asthma benefit most from inhaled fluticasone propionate. This finding aids in predicting treatment success for young children with recurrent asthma symptoms.

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology

Background:

  • Diagnosis and treatment of asthma in preschool children present significant challenges.
  • Identifying subgroups that respond to therapy is crucial for effective management.

Purpose of the Study:

  • To identify preschool children (12-47 months) with recurrent asthma symptoms most likely to respond to inhaled fluticasone propionate (200 microg/d).

Main Methods:

  • Analysis of pooled data from two 12-week multicenter studies.
  • Subgroup analysis based on symptom frequency and family history of asthma.

Main Results:

  • Children with frequent symptoms showed a significantly greater improvement in symptom-free days with fluticasone propionate compared to placebo (45% vs 25%).
  • Children with a family history of asthma also demonstrated significantly more symptom-free days and a higher proportion of exacerbation-free periods with fluticasone propionate.
  • No significant treatment effect was observed in children with less frequent symptoms or no family history of asthma.

Conclusions:

  • Frequent symptoms and a family history of asthma are key indicators for predicting a positive response to inhaled fluticasone propionate in preschool children.
  • These results can guide personalized treatment strategies for managing recurrent asthma symptoms in this age group.
Abstract

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