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Maternal atopy and parity.

J Sunyer1, J M Antó, J Harris

  • 1Unitat de Recerca Respiratòria i Ambiental, Institut Municipal Investigació Mèdica , Barcelona, Catalonia, Spain. jsunyer@imim.es

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
|October 10, 2001
PubMed
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Maternal atopy, a predisposition to allergic reactions, was inversely related to the number of children women had. This finding challenges the idea that family size influences child atopy.

Area of Science:

  • Allergy and Immunology
  • Reproductive Epidemiology
  • Pediatric Allergy

Background:

  • Previous studies linked larger family size and higher birth order to increased hayfever and positive skin prick tests.
  • This association may be influenced by maternal atopy, prompting further investigation.

Purpose of the Study:

  • To examine the relationship between maternal atopy and the number of offspring.
  • To investigate the influence of maternal atopy on parity in three European cohorts.

Main Methods:

  • Recruited 1487 mothers and children for the Asthma Multi-centre Infants Cohort Study (AMICS).
  • Utilized three concurrent European cohorts (UK, Spain) with identical research protocols.
  • Assessed maternal and paternal atopy via skin prick tests.

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Main Results:

  • Maternal atopy showed an inverse relationship with the number of offspring across all three cohorts (adjusted ORs 0.71, 0.79, 0.26; P=0.002).
  • This association persisted when atopy was defined by individual allergens (Der p 1 or grass pollen) and was not confounded by maternal age, smoking, or social class.
  • Neither maternal asthma nor paternal atopy were associated with the number of offspring.

Conclusions:

  • The inverse association between maternal atopy and parity challenges the established role of family size in child atopy.
  • Further research in diverse populations is needed to confirm these findings and understand the implications for child allergy prevalence.