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Typing of Clostridium difficile.

J S Brazier1

  • 1Anaerobe Reference Unit, Public Health Laboratory, University Hospital of Wales, Heath Park, Cardiff, UK.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|October 10, 2001
PubMed
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Clostridium difficile infection (CDI) is a common hospital-acquired condition. This review examines various molecular typing methods used to understand CDI epidemiology and control outbreaks.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Epidemiology

Background:

  • Clostridium difficile is a significant cause of nosocomial infections, particularly gastrointestinal disease.
  • Antibiotic use is a primary risk factor for C. difficile infection (CDI).
  • CDI outbreaks frequently occur in healthcare settings due to cross-infection.

Purpose of the Study:

  • To review the evolution and application of molecular typing methods for C. difficile.
  • To discuss the insights gained from epidemiological studies of CDI.
  • To provide a historical perspective on C. difficile typing techniques.

Main Methods:

  • Review of published literature on C. difficile typing methods since the 1980s.
  • Analysis of the effectiveness and limitations of various fingerprinting techniques.

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  • Synthesis of epidemiological data derived from typing studies.

    • Main Results:

    • Multiple molecular typing methods have been developed and applied to study C. difficile.
    • These methods have been crucial in tracking C. difficile transmission and understanding outbreak dynamics.
    • Significant advancements in characterizing C. difficile strains and their epidemiology have been achieved.

    Conclusions:

    • Molecular typing remains essential for managing and preventing C. difficile infections.
    • Understanding the historical application of typing methods informs current epidemiological surveillance.
    • Continued development and application of advanced typing techniques are vital for controlling CDI.