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Related Experiment Videos

Extra-intestinal infections caused by Clostridium difficile.

J M García-Lechuz1, S Hernangómez, R S Juan

  • 1Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain. lechuz@efd.net

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|October 10, 2001
PubMed
Summary

Extra-intestinal Clostridium difficile infections are rare, occurring in about 1% of isolates. These infections, often polymicrobial, can happen without typical symptoms and their clinical significance requires careful interpretation.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Clostridium difficile is a common cause of intestinal infections.
  • Extra-intestinal infections caused by Clostridium difficile are infrequently reported.
  • Understanding the incidence and characteristics of extra-intestinal C. difficile is important for clinical management.

Purpose of the Study:

  • To determine the incidence of extra-intestinal infections caused by Clostridium difficile.
  • To analyze the clinical features and outcomes of patients with extra-intestinal C. difficile isolates.

Main Methods:

  • Retrospective review of a 10-year microbiology laboratory database.
  • Identification and analysis of Clostridium difficile isolates from extra-intestinal sources.

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  • Review of clinical records for 17 patients with extra-intestinal C. difficile.

    • Main Results:

    • 21 out of 2034 (1.08%) Clostridium difficile isolates were from extra-intestinal sources.
    • Extra-intestinal C. difficile was isolated from various sites, including abdominal structures, bloodstream, brain, and foot.
    • Most extra-intestinal isolates were non-toxigenic and occurred in polymicrobial flora, often without diarrhea or prior antibiotic use.

    Conclusions:

    • Isolation of Clostridium difficile from extra-intestinal sites is uncommon.
    • Clinical significance of extra-intestinal C. difficile should be interpreted cautiously.
    • Further research is needed to fully understand the role of C. difficile in non-intestinal infections.