Related Experiment Video

Updated: Jul 30, 2026

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
07:10

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

[Diastolic dysfunction in human immunodeficiency virus infection]

F Hernández Hernández1, R Gascueña Rubia, P Escribano Subías

  • 1Servicio de Cardiología.Hospital Universitario 12 de Octubre, Madrid, Spain. fhernandezh@medynet.com

Revista Espanola De Cardiologia
|October 10, 2001
PubMed

Insights

Patients with human immunodeficiency virus (HIV) infection frequently exhibit silent echocardiographic abnormalities, including diastolic dysfunction. These findings suggest a direct cardiac impact of HIV, particularly in those with compromised immune status.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Virology

Context:

  • Human immunodeficiency virus (HIV) infection can affect multiple organ systems.
  • Cardiac involvement in HIV is often subclinical in early stages.
  • Echocardiography is a key tool for assessing cardiac structure and function.

Purpose:

  • To determine the prevalence and characteristics of echocardiographic abnormalities in asymptomatic HIV-infected patients.
  • To compare cardiac findings in HIV patients with a healthy control group.
  • To investigate the relationship between immunologic status and cardiac dysfunction in HIV.

Summary:

  • Transthoracic echocardiography revealed abnormal left ventricular relaxation and filling patterns in 125 HIV patients compared to 47 controls.
  • Segmental wall-motion abnormalities (15%) and pericardial effusion (7.2%) were observed in the HIV group.
  • Systolic function and left ventricular dimensions were normal and did not differ significantly between groups.

Impact:

  • Silent echocardiographic abnormalities are common in HIV patients, indicating a potential direct myocardial effect of the virus.
  • Diastolic dysfunction in HIV is linked to a poorer immunologic status (lower CD4 counts).
  • Further prospective studies are necessary to understand the clinical prognosis of these asymptomatic cardiac changes.
Abstract

More Related Videos

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models09:54

Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease08:57

Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease

Published on: May 22, 2026

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Inhibitors of Virion Maturation and Assembly01:19

Inhibitors of Virion Maturation and Assembly

As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...