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Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies
Published on: January 7, 2019
[Diastolic dysfunction in human immunodeficiency virus infection].
F Hernández Hernández1, R Gascueña Rubia, P Escribano Subías
1Servicio de Cardiología.Hospital Universitario 12 de Octubre, Madrid, Spain. fhernandezh@medynet.com
Revista Espanola De Cardiologia
|October 10, 2001
Summary
Patients with human immunodeficiency virus (HIV) infection frequently exhibit silent echocardiographic abnormalities, including diastolic dysfunction. These findings suggest a direct cardiac impact of HIV, particularly in those with compromised immune status.
Area of Science:
- Cardiology
- Infectious Diseases
- Virology
Context:
- Human immunodeficiency virus (HIV) infection can affect multiple organ systems.
- Cardiac involvement in HIV is often subclinical in early stages.
- Echocardiography is a key tool for assessing cardiac structure and function.
Purpose:
- To determine the prevalence and characteristics of echocardiographic abnormalities in asymptomatic HIV-infected patients.
- To compare cardiac findings in HIV patients with a healthy control group.
- To investigate the relationship between immunologic status and cardiac dysfunction in HIV.
Summary:
- Transthoracic echocardiography revealed abnormal left ventricular relaxation and filling patterns in 125 HIV patients compared to 47 controls.
- Segmental wall-motion abnormalities (15%) and pericardial effusion (7.2%) were observed in the HIV group.
- Systolic function and left ventricular dimensions were normal and did not differ significantly between groups.
Impact:
- Silent echocardiographic abnormalities are common in HIV patients, indicating a potential direct myocardial effect of the virus.
- Diastolic dysfunction in HIV is linked to a poorer immunologic status (lower CD4 counts).
- Further prospective studies are necessary to understand the clinical prognosis of these asymptomatic cardiac changes.
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