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Avoidance of multiple pregnancies after ovulation induction by supernumerary preovulatory follicular reduction
C Albano1, P Platteau, D Nogueira
1Centre for Reproductive Medicine, Dutch-speaking Brussels Free University, Brussels, Belgium. lriaaoc@az.vub.ac.be
Objective:
To evaluate the effect of supernumerary preovulatory follicular reduction as an approach to avoid multiple pregnancies in ovulation induction or superovulation cycles.
Design:
Retrospective study.
Setting:
Tertiary referral center.
Patient(S):
In 26 cycles, 24 patients underwent ovulation induction or superovulation with either clomiphene citrate or hMG.
Intervention(S):
Selective follicle aspiration was performed before hCG administration.
Main Outcome Measure(S):
Clinical pregnancy rate and numbers of multiple pregnancies.
Result(S):
A mean number of 4.5 follicles with a diameter > or =15 mm and a mean number of 4.5 follicles with a diameter < or =14 mm were observed before hCG administration. A mean number of 2.3 follicles with a diameter > or =15 mm and a mean number of 1.8 follicles with a diameter < or =14 mm were aspirated before the hCG administration. Seven singleton pregnancies (26.9% per cycle) ensued from the treatment.
Conclusion(S):
Aspiration of supernumerary follicles after ovulation induction or superovulation seems to be a valid approach to avoid multiple pregnancies without affecting pregnancy rate.