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Updated: Oct 4, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
Synthesis and biological evaluation of novel bisindolylmaleimides that inhibit vascular endothelial cell
M F Braña1, L Añorbe, G Tarrasón
1Departamento de Química Orgánica y Farmacéutica, Facultad de CC. Experimentales y Técnicas, Universidad San Pablo CEU, Urb. Montepríncipe, Boadilla del Monte, 28668, Madrid, Spain. mfbrana@ceu.es
Abstract:
A novel class of bisindolylmaleimides were synthesized and antiproliferative activities (HUVECs and three tumor cell lines) of these compounds were investigated. Two water-soluble derivatives, 10 and 12, possessing a dimethylaminoalkoxy side chain in their structure, showed interesting activity and selectivity on HUVECs proliferation.
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