Transcription-induced cytosine-to-thymine mutations are not dependent on sequence context of the target cytosine
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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images
Published on: September 7, 2017
1Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.
Journal of Bacteriology
|October 10, 2001
Abstract:
We showed previously that transcription of a plasmid-borne kan allele increases C-to-T mutations in the nontranscribed strand. Using two new plasmid-borne kan alleles, one cmp allele, and a chromosomal kan allele, we found in this study that transcription-induced mutations are not limited to specific genes, alleles, or locations and are likely to be a general property of transcript elongation in Escherichia coli.
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