Stability of sufentanil in human plasma samples
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Updated: Oct 4, 2026

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Published on: March 11, 2017
C Dufresne1, P Favetta, C Paradis
1Department of Clinical Pharmacy, Pharmacokinetics, and Drug Evaluation, Institute of Pharmaceutic and Biologic Sciences, Claude Bernard Lyon 1 University (UCBL), Lyon, France.
Abstract:
The stability of sufentanil in human plasma kept under various storage conditions was investigated. Extraction was performed using solid phase extraction with new mixed-mode cation exchange Oasis MCX columns; quantification was carried out using gas chromatography equipped with a mass spectrometry detector. When plasma was left at 4 degrees C in nonsilanized tubes, concentrations of sufentanil decreased significantly during the first hour. In plasma samples kept at -25 degrees C for 8 hours in nonsilanized glass tubes, a significant decrease of sufentanil concentrations was found, with an average loss of 10.1% of the initial concentration. A significant decrease occurred when plasma was kept in silanized glass tubes for 12 hours at -25 degrees C. The current study emphasizes the importance of sampling and storage conditions for an accurate determination of sufentanil concentration in plasma.
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