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[Linkage disequilibrium analysis of chromosome 22 and schizophrenia in a Chinese population]
1Institute of Mental Health, The First Affiliated Hospital, West China University of Medical Sciences, Chengdu, Sichuan, 610041 P.R. China. caiguiqing@21cn.com
Objective:
To explore the molecular genetic relations of chromosome 22 and schizophrenia and locate the susceptibility gene of schizophrenia.
Methods:
Six dinucleotide tandem repeat loci on chromosome 22 were chosen to analyze 126 affected sib-pair nuclear families of schizophrenia in Chinese population by fluorescent labeled auto-mated genotyping and transmission/ disequilibrium test(TDT).
Results:
The TDT-chi square value of IL2Rbeta was 25.30(P=0.01), which suggests there is linkage disequilibrium between IL2R beta and schizophrenia. The P vaules of the other five loci (D22S944, D22S264, D22S303, D22S278 and CYP2D6) were greater than 0.05.
Conclusion:
A susceptive gene of schizophrenia may be located in IL2Rbeta locus or adjacent region.