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Hyperhomocysteinemia in advanced age.

H J Naurath1

  • 1Geriatrische Klinik, Friedrich-Ebert-Krankenhaus, Neumuenster, Germany.

Clinical Chemistry and Laboratory Medicine
|October 11, 2001
PubMed
Summary

Elderly individuals are at high risk for vitamin deficiency and hyperhomocysteinemia. Supplementation with vitamins B6, B12, and folate effectively lowers homocysteine levels in older adults.

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Area of Science:

  • Gerontology
  • Nutritional Science
  • Biochemistry

Background:

  • Vitamin deficiency is uncommon in affluent societies, but older adults represent a significant risk group.
  • Lowered vitamin concentrations in the blood are more frequent with advanced age.
  • Consequences of vitamin deficiency in the elderly, particularly hyperhomocysteinemia, are not well understood.

Purpose of the Study:

  • To investigate the prevalence and risk factors of hyperhomocysteinemia in the elderly.
  • To evaluate the efficacy of vitamin supplementation in reducing elevated homocysteine levels in older adults.
  • To explore the potential benefits of homocysteine-lowering treatment for chronic disease prevention in the elderly.

Main Methods:

  • Observational studies assessing vitamin status and homocysteine levels in aging populations.
  • Analysis of factors contributing to hyperhomocysteinemia risk, including physical and social conditions.
  • Clinical trials administering specific B vitamins (B6, B12, folate) to older individuals with elevated homocysteine.

Main Results:

  • Hyperhomocysteinemia is frequently observed in advanced age.
  • Impaired physical condition and social situation are associated with an increased risk of hyperhomocysteinemia.
  • Supplementation with vitamins B6, B12, and folate significantly reduced elevated serum homocysteine concentrations in older participants.

Conclusions:

  • Hyperhomocysteinemia is a common issue in the elderly, influenced by age and socio-physical factors.
  • Vitamin B6, B12, and folate administration is an effective strategy for lowering homocysteine levels in this demographic.
  • Further research is crucial to understand the full impact of homocysteine-lowering treatments on chronic disease prevention and overall health in older adults.

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