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Cladospolide D, a new 12-membered macrolide antibiotic produced by Cladosporium sp. FT-0012

H Zhang¹, H Tomoda, N Tabata

¹The Kitasato Institute, Tokyo, Japan.

The Journal of Antibiotics

|October 11, 2001

Abstract:

A new antibiotic termed cladospolide D was isolated along with the known cladospolides A and B from the fermentation broth of Cladosporium sp. FT-0012 by solvent extraction, ODS column chromatography and preparative HPLC. The structure of cladospolide D was deduced to be (E)-2-dodecen-5-hydroxy-11-olide-4-one. Cladospolide D showed antifungal activity against Pyricularia oryzae and Mucor racemosus.

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