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Related Experiment Videos

Doping with growth hormone.

M Bidlingmaier1, Z Wu, C J Strasburger

  • 1Medizinische Klinik, Klinikum der LMU-Innenstadt, Munich, Germany. bidlingmaier@medinn.med.uni-muenchen.de

Journal of Pediatric Endocrinology & Metabolism : JPEM
|October 11, 2001
PubMed
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Athletes may be using recombinant human growth hormone (hGH) for performance enhancement despite a lack of scientific evidence. Detecting this naturally occurring substance in the body presents significant challenges for anti-doping efforts.

Area of Science:

  • Sports Science
  • Endocrinology
  • Anti-Doping Research

Background:

  • Recombinant human growth hormone (hGH) use among athletes is rumored to be widespread, particularly following the Sydney Olympic Games.
  • Despite media claims, concrete evidence of hGH abuse by athletes is scarce, often relying on anecdotal reports rather than laboratory findings.
  • The lack of a validated detection method for hGH doping contributes to its perceived attractiveness among athletes.

Purpose of the Study:

  • To investigate the scientific basis for athlete use of hGH, questioning its purported performance-enhancing effects.
  • To explore the scientific challenges in detecting the abuse of naturally occurring substances like hGH in sports.

Main Methods:

  • This article reviews existing scientific literature regarding the effects of hGH on workload capacity in healthy adults.

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  • It discusses the scientific and technical difficulties associated with developing reliable methods for detecting hGH doping.
  • The review addresses the discrepancy between reported athlete usage and the limited empirical evidence of efficacy.

    • Main Results:

    • There is a lack of controlled studies demonstrating significant improvements in workload capacity or athletic performance in healthy adults following hGH administration.
    • Detecting exogenous hGH is scientifically challenging due to its endogenous nature and intermittent administration patterns.
    • Rumors and perceived benefits, rather than proven efficacy, appear to drive athlete interest in hGH.

    Conclusions:

    • The scientific evidence supporting the performance-enhancing claims of hGH in athletes is currently insufficient.
    • Developing effective and reliable anti-doping tests for hGH remains a significant scientific hurdle.
    • Further research is needed to understand the true effects of hGH and to establish robust detection methods.