Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Noise-induced transition in excitable neuron models.

S Tanabe¹, K Pakdaman

¹Department of Systems and Human Science, School of Engineering Science, Osaka University, Toyonaka, Japan.

Biological Cybernetics

|October 11, 2001

Summary

Noisy stimulation can induce a critical transition in the Hodgkin-Huxley neuron model. This noise-induced transition alters neuronal dynamics, impacting spike timing precision in neuronal ensembles.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evolution of aging: individual life history trade-offs and population heterogeneity account for mortality patterns across species.

Journal of evolutionary biology·2014

Same author

A note on convergence under dynamical thresholds with delays.

IEEE transactions on neural networks·2008

Same author

Asymptotic behavior of irreducible excitatory networks of analog graded-response neurons.

IEEE transactions on neural networks·2008

Same author

Comparison of nonmetal and metal hydrophilic photosensitizer, ATX-S10 (Na) and ATN-2, binding with human serum proteins using spectrophotometry.

Photochemistry and photobiology·2004

Same author

Organochlorine pesticides and polychlorinated biphenyls in California sea lions.

Environmental pollution (Barking, Essex : 1987)·2004

Same author

Widespread contamination by tris(4-chlorophenyl)methane and tris(4-chlorophenyl)methanol in cetaceans from the North Pacific and Asian coastal waters.

Environmental pollution (Barking, Essex : 1987)·2004

Area of Science:

Computational Neuroscience
Theoretical Neuroscience
Biophysics

Background:

Previous studies focused on noise-induced variability in neuron discharge times.
The effect of noise on stationary distributions of neuronal variables remains less explored.

Purpose of the Study:

To investigate the influence of noisy stimulation on the Hodgkin-Huxley neuron model's stationary distributions.
To characterize the nature of noise-induced transitions in neuronal models.
To explore the functional implications of these transitions for neuronal coding.

Main Methods:

Analysis of stationary distributions of membrane potential and gating variables in the Hodgkin-Huxley model.
Investigation of a reduced one-dimensional active rotator model to understand the underlying dynamics.
Assessment of the impact on spike timing precision in neuronal ensemble models.

Main Results:

A critical intermediate noise range was identified, causing drastic qualitative changes in distribution shapes.
Distributions shifted from unimodal to bimodal for membrane potential and sodium activation variable.
The noise-induced transition in the active rotator model was linked to a deterministic bifurcation.

Conclusions:

The Hodgkin-Huxley model exhibits a noise-induced transition, not a gradual change, with increasing noise intensity.
This transition is associated with deterministic bifurcations in simplified models.
The identified noise-induced transition has potential functional significance in neuronal coding and spike timing precision.

Related Experiment Videos