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[The effects of PDGF-AB on pro alpha 1 (III). mRNA expression of fibroblasts]
1Department of Burn Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
Objective:
To investigate the mechanism of PDGF-AB to promote wound healing and its role during the process of scar formation.
Methods:
In vitro cultured fibroblasts of human normal skin and hypertrophic scar were treated with PDGF-AB. The expression of Pro alpha 1 (III) mRNA of the fibroblasts was evaluated by in situ hybridization technique.
Results:
PDGF-AB could increase Pro alpha 1 (III) mRNA expression of fibroblasts of both normal skin and hypertrophic scar in a dose-dependent manner. However, the effect of PDGF-AB on hypertrophic scar fibroblasts was stronger.
Conclusions:
PDGF-AB may promote wound healing by stimulating extracellular matrix synthesis, e.g. collagen. PDGF-AB may also play a role in scar formation through collagen deposition.
