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[Experimental study on selective thrombolytic activity of pro-urokinase]
1Department of Plastic Surgery, 455th Hospital, People's Liberation Army, Shanghai 200052, PR China.
Objective:
To evaluate the valve of pro-urokinase as a selective thrombolytic agent in microsurgery.
Methods:
The levators muscle model in rats was used to investigate the effect of pro-urokinase on dissolving ischemic thrombi and fibrinogenolytic activities in circulation by local infusion. The tissue microcirculation, pathologic appearance of rat lungs and muscles, and general fibrinogenolytic activities were observed.
Results:
The thrombolytic rate of pro-urokinase was 92.3% (P < 0.05), the positive rate of D-dime was 83.3%(P < 0.05). No significant change of alpha 2-PI was observed on general fibrinogenolytic activities(P > 0.05).
Conclusions:
It is suggested that pro-urokinase can be used to dissolve the thrombi in microcirculation of free tissue transplantation without affect general fibrinogenolytic activities. It is safe to use pro-urokinase in free tissue transplantation.