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Novel thrombin inhibitors with azaphenylalanine scaffold
A Zega1, A Trampus-Bakija, M Fortuna
1Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
Die Pharmazie
|October 12, 2001
Abstract:
In this paper the synthesis and antithrombotic activity of a series of novel thrombin inhibitors with azaphenylalanine scaffold are described. By systematic structural modifications for this series we have identified optimal groups for achieving nanomolar potency, that led to potent inhibitors of thrombin with Ki values up to 11 nM.