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Structurally related immunological effects of triterpenoid saponins

M Bernhardt1, C Sturm, K H Shaker

  • 1Faculty of Biology, Chemistry and Geology, University of Bayreuth, Germany.

Die Pharmazie
|October 12, 2001
PubMed

The influence of the triterpenoid saponins 1-10 has been investigated on murine spleenocytes in the lymphocyte transformation test and on murine macrophages in an phagocytosis assay. The lymphocyte transformation test and the phagocytosis assay showed that the tested compounds have no stimulating effect. However, a significant inhibition of lymphocyte proliferation by the triterpenoid saponins 2, 6 and 10 was demonstrated.

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