Related Experiment Video

Updated: Aug 1, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

Prevention of respiratory syncytial virus infection in high risk infants

A M Prince, R F Jacobs

    The Journal of the Arkansas Medical Society
    |October 12, 2001
    PubMed

    Insights

    Serious respiratory syncytial virus (RSV) illness in premature infants and those with chronic lung disease (CLD) can be reduced. Prophylaxis with Synagis is recommended for high-risk infants during the RSV season.

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Immunology

    Background:

    • Respiratory Syncytial Virus (RSV) poses a significant threat to vulnerable infant populations.
    • Premature infants and those with chronic lung disease (CLD) are at higher risk for severe RSV illness.

    Purpose of the Study:

    • To evaluate the effectiveness of Synagis prophylaxis in reducing serious RSV illness.
    • To identify high-risk infant groups who may benefit from RSV prophylaxis.

    Main Methods:

    • Administration of Synagis at a dose of 15 mg/kg intramuscularly monthly during the RSV season.
    • Ongoing clinical trials to assess Synagis use in infants with congenital heart disease (CHD) and cystic fibrosis.

    Main Results:

    • Synagis significantly reduces the incidence of serious RSV illness in premature infants and those with CLD.
    • Prophylaxis with Synagis is considered prudent for infants with CHD and cystic fibrosis.

    Conclusions:

    • Synagis is a safe and effective option for preventing serious RSV illness in high-risk infants.
    • Ease of administration makes Synagis the preferred choice for most high-risk children.

    More Related Videos

    An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay09:14

    An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay

    Published on: January 26, 2019

    Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses11:48

    Generation, Amplification, and Titration of Recombinant Respiratory Syncytial Viruses

    Published on: April 4, 2019

    Related Concept Videos

    Transmission-based Precautions II: Airborne and Protective Environment01:25

    Transmission-based Precautions II: Airborne and Protective Environment

    Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
    Airborne precautions:
    Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
    Common Respiratory Disorders01:31

    Common Respiratory Disorders

    Respiratory disorders, a prevalent health concern globally, are generally divided into two primary categories: upper and lower respiratory tract disorders. The categorization is based on the area of the respiratory system they affect.
    Upper respiratory disorders impact the airways above the vocal cords, encompassing areas like the nose, sinuses, and throat. Various conditions fall under this category, including the common cold and allergic rhinitis. These disorders can stem from several causes,...
    Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics01:23

    Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics

    Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
    Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla.  Benzonatate operates peripherally within the respiratory tract by anesthetizing...
    Pneumonia V: Nursing management and Prevention01:30

    Pneumonia V: Nursing management and Prevention

    Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
    The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
    Enhance airway patency
    Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed.
    Acute Respiratory Failure-V01:29

    Acute Respiratory Failure-V

    The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
    Ensure that patients are monitored continuously for their response to therapy, including changes in...
    Respiratory Syncytial Virus Disease01:29

    Respiratory Syncytial Virus Disease

    Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...