Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Beta cell failure: causes and consequences.

S E Kahn1

  • 1VA Puget Sound Health Care System, University of Washington, Seattle, Washington, USA.

International Journal of Clinical Practice. Supplement
|October 12, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring residual risk for diabetes and microvascular disease in the Diabetes Prevention Program Outcomes Study (DPPOS).

Diabetic medicine : a journal of the British Diabetic Association·2017
Same author

Steroid Sex Hormones, Sex Hormone-Binding Globulin, and Diabetes Incidence in the Diabetes Prevention Program.

The Journal of clinical endocrinology and metabolism·2015
Same author

The duodenal glucose load impacts the oral disposition index in healthy subjects.

Diabetic medicine : a journal of the British Diabetic Association·2015
Same author

Visceral abdominal fat accumulation predicts the conversion of metabolically healthy obese subjects to an unhealthy phenotype.

International journal of obesity (2005)·2015
Same author

Glucocorticoid receptor gene expression in adipose tissue and associated metabolic risk in black and white South African women.

International journal of obesity (2005)·2014
Same author

Diabetes autoantibodies do not predict progression to diabetes in adults: the Diabetes Prevention Program.

Diabetic medicine : a journal of the British Diabetic Association·2014
Same journal

Comparison of tacrolimus and cyclosporin A in CYP3A5 expressing Chinese de novo kidney transplant recipients: a 2-year prospective study.

International journal of clinical practice. Supplement·2015
Same journal

Efficacy and safety of basiliximab in liver transplantation for patients with hepatitis B virus-related diseases: a single centre study.

International journal of clinical practice. Supplement·2015
Same journal

Human parvovirus B19 infection induced pure red cell aplasia in liver transplant recipients.

International journal of clinical practice. Supplement·2015
Same journal

Interleukin-2 receptor antagonist compared with antithymocyte globulin induction therapy in kidney transplantation from donors after cardiac death.

International journal of clinical practice. Supplement·2015
Same journal

Effect of CYP3A5 polymorphism on the pharmacokinetics of tacrolimus and acute rejection in renal transplant recipients: experience at a single centre.

International journal of clinical practice. Supplement·2015
Same journal

Outcomes of standard dose EC-MPS with low exposure to CsA in DCD renal transplantation recipients with DGF.

International journal of clinical practice. Supplement·2015
See all related articles

Type 2 diabetes involves both insulin resistance and beta-cell dysfunction. Early insulin secretion defects impair glucose control, necessitating treatments addressing both issues.

Area of Science:

  • Endocrinology
  • Metabolic Diseases

Background:

  • Type 2 diabetes pathogenesis involves complex interactions between insulin resistance and beta-cell dysfunction.
  • Early alterations in insulin secretion are detectable in high-risk individuals before clinical diagnosis.

Purpose of the Study:

  • To examine the interplay between insulin secretion and insulin sensitivity in type 2 diabetes development.
  • To highlight the significance of early insulin secretion defects in disease progression.

Main Methods:

  • Analysis of insulin secretion patterns following glucose administration (oral and intravenous).
  • Comparison of insulin secretion and sensitivity in healthy individuals versus those at risk for diabetes.
  • Evaluation of standardized hyperbolic curves representing the feedback loop between secretion and sensitivity.

Related Experiment Videos

Main Results:

  • Deviations from normal hyperbolic curves indicate combined defects in insulin secretion and sensitivity in at-risk individuals.
  • Reduced early-phase insulin response leads to impaired suppression of hepatic glucose production.
  • Impaired hepatic glucose regulation contributes to postprandial hyperglycemia.

Conclusions:

  • Effective type 2 diabetes management requires addressing both insulin secretion deficits and insulin resistance.
  • Emerging therapies focus on stimulating early insulin secretion and improving insulin sensitivity.