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Zolmitriptan--a 5-HT1B/D agonist, alcohol, and aggression in mice
R M de Almeida1, E M Nikulina, S Faccidomo
1Department of Psychology, Tufts University, Medford, MA 02155, USA
Psychopharmacology
|October 12, 2001
Summary
Zolmitriptan, an anti-migraine drug, effectively reduces aggression in mice, including alcohol-induced aggression. These anti-aggressive effects are mediated by post-synaptic 5-HT1B/D receptors.
Area of Science:
- Neuroscience
- Pharmacology
- Behavioral Science
Background:
- Zolmitriptan is a 5-HT1B/D receptor agonist used for migraines.
- Its central nervous system penetration suggests potential for other therapeutic effects, including anti-aggression.
Purpose of the Study:
- To investigate zolmitriptan's anti-aggressive effects in mice.
- To determine if these effects are mediated by pre- or post-synaptic 5-HT1B/D receptors.
- To assess zolmitriptan's efficacy on both species-typical and alcohol-heightened aggression.
Main Methods:
- Resident-intruder confrontation tests in male CFW mice.
- Pharmacological blockade of 5-HT1B receptors using GR 127935.
- Concurrent administration of zolmitriptan and alcohol.
- Assessment of zolmitriptan's effects after 5,7-DHT-induced lesions of serotonergic neurons.
Main Results:
- Zolmitriptan demonstrated specific anti-aggressive effects, antagonized by GR 127935, confirming 5-HT1B receptor involvement.
- Zolmitriptan effectively reduced alcohol-heightened aggression.
- Lesions targeting presynaptic receptors did not alter zolmitriptan's anti-aggressive effects.
Conclusions:
- Zolmitriptan is an effective and specific anti-aggressive agent.
- Its effects are likely mediated by the activation of post-synaptic 5-HT1B/D receptors.
