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Differential effects of delta 9-THC on spatial reference and working memory in mice
S A Varvel1, R J Hamm, B R Martin
1Department of Pharmacology, VCU, Richmond, VA 23298, USA.
Psychopharmacology
|October 12, 2001
Summary
Delta9-tetrahydrocannabinol (THC) selectively impairs working memory at lower doses than reference memory. These memory deficits are mediated by cannabinoid receptors and are more sensitive than other THC effects.
Area of Science:
- Neuroscience
- Pharmacology
- Cognitive Science
Background:
- Marijuana is widely used, prompting research into therapeutic cannabinoid uses.
- Understanding delta9-tetrahydrocannabinol (THC)-induced memory impairment is crucial.
Purpose of the Study:
- To determine if delta9-THC differentially affects spatial working and reference memory.
- To investigate the receptor mechanism of delta9-THC's memory effects.
- To compare delta9-THC's effects with scopolamine and phencyclidine.
Main Methods:
- Utilized two versions of the Morris water maze for working and reference memory tasks.
- Assessed other delta9-THC effects via standard tests for hypomotility, antinociception, catalepsy, and hypothermia.
Main Results:
- Delta9-THC disrupted working memory at lower doses (3.0 mg/kg) than reference memory (100 mg/kg).
- Performance deficits were reversed by SR 141716A, indicating a CB1 receptor mechanism.
- Delta9-THC's effects mimicked scopolamine's selective working memory disruption.
Conclusions:
- Delta9-THC selectively impairs working memory via CB1 receptor activation.
- These memory impairments are more sensitive to delta9-THC than other tested pharmacological effects.