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Internuclear ophthalmoplegia in progressive supranuclear palsy
Journal of the Neurological Sciences
|July 1, 1975
Summary
Progressive supranuclear palsy (PSP) can cause internuclear ophthalmoplegia, a rare eye movement disorder. This study observed this condition in 4 of 13 PSP patients, suggesting medial longitudinal fasciculus involvement.
Area of Science:
- Neurology
- Ophthalmology
- Neuroscience
Background:
- Progressive supranuclear palsy (PSP) is a neurodegenerative disease.
- Internuclear ophthalmoplegia (INO) is an eye movement disorder typically associated with brainstem lesions.
- INO has not been previously documented in PSP.
Purpose of the Study:
- To report the occurrence of internuclear ophthalmoplegia in patients with progressive supranuclear palsy.
- To investigate potential neurological underpinnings of INO in PSP.
Main Methods:
- Observational study over a 4-year period.
- Clinical assessment of 13 patients diagnosed with progressive supranuclear palsy.
- Documentation of ocular motor findings, specifically internuclear ophthalmoplegia.
Main Results:
- Varying degrees of anterior internuclear ophthalmoplegia were observed in 4 out of 13 (31%) studied cases of PSP.
- This represents the first reported association between INO and PSP.
Conclusions:
- The presence of internuclear ophthalmoplegia in PSP suggests involvement of the medial longitudinal fasciculus (MLF) in the degenerative process.
- This finding expands the spectrum of clinical manifestations in progressive supranuclear palsy.