Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

Sexually Transmitted Infections

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...

Herpes

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...

Genital Herpes

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...

Cryptococcal Meningitis

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...

Inhibitors of Virion Maturation and Assembly

Inhibitors of Virion Maturation and Assembly

As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Does concentrated growth factor provide better outcomes than platelet-rich fibrin or arthrocentesis in the management of temporomandibular disorders?

International journal of oral and maxillofacial surgery·2026

Same author

From Ground to Excited State: Revealing Bond Polarity Change via K<sup>-2</sup>V Spectroscopy and Brillouin Inverse Theorem (BIT).

The journal of physical chemistry letters·2025

Same author

Biosafety and Withdrawal Period of In-Feed Administered Antiparasitic Drug Emamectin Benzoate in Cirrhinus mrigala (Hamilton, 1822).

Journal of veterinary pharmacology and therapeutics·2025

Same author

Atezolizumab plus bevacizumab in advanced Merkel cell carcinoma: A prospective study.

Oral oncology·2024

Same author

Modified realist evaluation of a complex, multi-centred, multi-intervention programme.

Journal of public health (Oxford, England)·2023

Same author

UNDERSTANDING THE LONG-TERM INTERPLAY BETWEEN GLUCOCORTICOIDS, PARATHYROID HORMONE LEVELS, AND OSTEOPOROSIS IN PATIENTS.

Georgian medical news·2023

Search research articles

Related Experiment Video

Updated: Jul 18, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

Human immunodeficiency virus and the peripheral nervous system workshop.

F J Brinley¹, C A Pardo, A Verma

¹Office of Infection and Immunity, National Institute of Neurological Disorders and Stroke, 6001 Executive Blvd, Room 2114, Bethesda, MD 20892-9521, USA. fb18u@nih.gov

Archives of Neurology

|October 27, 2001

Summary

This workshop reviewed human immunodeficiency virus-associated peripheral neuropathies, identifying key research areas. Recommendations guide future studies on these neurological complications.

More Related Videos

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Humanized NOD/SCID/IL2rγ^null (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

Related Experiment Videos

Last Updated: Jul 18, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Humanized NOD/SCID/IL2rγ^null (hu-NSG) Mouse Model for HIV Replication and Latency Studies

Published on: January 7, 2019

Area of Science:

Neurology
Virology
Neuroimmunology

Background:

Peripheral neuropathies are a significant complication of human immunodeficiency virus (HIV) infection.
Understanding the mechanisms and optimal management of HIV-associated peripheral neuropathies is crucial.

Purpose of the Study:

To comprehensively review the current knowledge of HIV-associated peripheral neuropathies.
To guide future research initiatives for the National Institute of Neurological Disorders and Stroke.

Main Methods:

Convened a multidisciplinary workshop on September 18-19, 2000.
Brought together experts from diverse fields including neurology, virology, and neuroimmunology.
Summarized meeting highlights and developed consensus-based research recommendations.

Main Results:

Facilitated a lively discussion on data interpretation and experimental approaches.
Identified critical areas for future research in HIV-associated neuropathies.
Established a consensus judgment on the most important research priorities.

Conclusions:

The workshop provided a vital platform for multidisciplinary exchange on HIV-related neurological disorders.
Consensus recommendations will direct future research efforts toward understanding and treating these neuropathies.