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Post-stroke violent adventitial movement responsive to levo-dopa/carbi-dopa therapy.
E P Frates1, D T Burke, H Chae
1Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA 02114, USA.
Brain Injury
|October 12, 2001
Summary
This case study shows levodopa/carbidopa effectively treated post-stroke tremor in a patient with a basal ganglia lesion. The medication significantly reduced tremor amplitude and resting tremor, demonstrating its therapeutic potential.
Area of Science:
- Neurology
- Neuroscience
- Movement Disorders
Background:
- Cerebrovascular accident (stroke) can lead to debilitating post-stroke tremor.
- Previous treatment strategies for post-stroke tremor have shown varied success.
Observation:
- A patient experienced a violent tremor and movement disorder following a left thalamic and left superior cerebellar artery infarction with basal ganglia lacunar infarction.
- The tremor was unresponsive to haloperidol treatment.
Findings:
- Administration of levodopa/carbidopa led to a dramatic reduction in tremor amplitude.
- Complete cessation of resting tremor was observed.
- The medication's efficacy was confirmed through withdrawal and reintroduction, correlating with symptom resolution.
Implications:
- Levodopa/carbidopa represents a promising therapeutic option for managing specific types of post-stroke tremor, particularly those associated with basal ganglia lesions.
- This case highlights the importance of considering dopaminergic agents in treating movement disorders after stroke.
- Further research into targeted pharmacological interventions for post-stroke neurological deficits is warranted.